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Across seven randomized controlled trials involving approximately 680 adult participants, mazdutide demonstrated a mean weight loss of 6.22%, with non-diabetic individuals achieving reductions of up to 8.44% in body weight

When you can simultaneously suppress appetite via GLP-1 and GIP, improve insulin sensitivity, and turn the metabolic furnace up via glucagon, the body composition consequences start to look qualitatively different from what monotherapy can produce